University of California, Davis - Amaral and Bennett

The dataset includes anatomical, field map, and DTI sequences from 56 macaques. The data was acquired in two-time slots: 2007 (28 macaques) and 2009 (19 macaques). A subset of 9 animals was scanned at 2 years of age as part of a separate study and are provided in this collection.

Usage Agreement

Creative Commons – Attribution-NonCommercial Share Alike (CC-BY-NC-SA)- Standard INDI data sharing policy. Prohibits use of the data for commercial purposes.

Species

Macaca mulatta

Scanner Specifications

Sample Description

Click here for the full sample description (.csv)

Scan Procedures and Parameters

Ethics approval: All scans were performed with approval of the University of California Davis, Institutional Animal Care and Use Committee (IACUC) protocol numbers: 12139, 15275, 16870, 16135, and 17774.

Animal care and housing: non-human primates were born at the California National Primate Research Center (CNPRC) in the spring of 2007. Infants were raised by their biological mothers in outdoor, half-acre enclosures that housed 75-120 animals made up of several matrilines. The subjects that made up this cohort were selected from seven different enclosures, and six subjects came from a particular enclosure. Subjects were selected to balance social rank as much as possible and to have mothers that had a proven history of excellent rearing practices and general health. Subject selection was based on the following characteristics of the mother: (1) rank of matriline (high, n = 8; middle, n = 9; low, n = 10); (2) previous reproductive experience (multiparous, n = 25; primiparous, n = 3); and (3) absence of previous medical problems, such as diabetes and arthritis.

Scanning preparations

Anesthesia procedures:

  • 2007 cohort: non-human primates were anesthetized with Propofol mixed with saline administered thru an IV catheter.
  • 2009 cohort: non-human primates were anesthetized with Propofol mixed with saline administered intravenously.

    • Time between anesthesia and scanning: Generally 15-30 minutes from initial sedation to beginning of scan acquisition.

    Head fixation:

  • 2007 cohort: non-human primate heads were surrounded with padding and placed in a 32-channel head coil and fixed in place with padded adjusters in the supine (face up) position.
  • 2009 cohort: non-human primates were placed in an MRI-compatible stereotaxic apparatus with a 3-inch diameter knee/surface receiving coil attached. The center of the knee coil was placed at A-P zero of the stereotaxic apparatus, directly over the head of the animal.

    • Position in scanner and procedure used:

  • 2007 cohort: supine (face up) position.
  • 2009 cohort: head first prone.

    • Contrast agent: None.

    During scanning

    Physiological monitoring:

  • 2007 cohort: SpO2, pulse, and respiration were monitored during the scanning sessions.

    • Additional procedures:

  • 2007 cohort: monkeys were intubated and provided with oxygen.
  • 2009 cohort: monkeys were intubated and provided with oxygen. A vitamin E capsule was placed on the left side of the head, and taped to the ear bar of the stereotaxis apparatus to indicate which was the left side of the brain.

    • Scan sequences

    Publications

    Personnel

  • David G. Amaral, PhD - Department of Psychiatry and Behavioral Sciences and The MIND Institute, University of California Davis.
  • Julia Scott, PhD - School of Engineering, Santa Clara University.
  • Jeffrey Bennett - Department of Psychology, University of California Davis.

    • Acknowledgements

    We would like to thank the CNPRC staff and scanner operators Kelly Wells and Sarah Liston.

    Funding

    This project was funded by NIH grants NS16980, R37 MH 57502, and R01MH041479.

    Usage notes

  • 2007 cohort: MRI scanning was performed at 9-time points: 1 week, 4 weeks, 8 weeks, 13 weeks, 26 weeks, 39 weeks, 52 weeks, 156 weeks (3 years), and 250 weeks (5 years). Nine adult monkeys (4 male and 5 female, ages 8-11 years old) were also imaged as part of the study.
  • 2009 cohort: MRI scanning was performed at 7-time points: 1 week, 4 weeks, 8 weeks, 13 weeks, 26 weeks, 39 weeks, and 52 weeks. Eight animals also received scans at 104 weeks (2 years). The protocol for most scan time points is the same. However, because of time constraints or difficulties with anesthesia, an abbreviated protocol was applied. The abbreviated protocol does not include field maps.

    • Downloads

    Click here to download the data. Users will first be prompted to log on to NITRC and will need to register with the 1000 Functional Connectomes Project website on NITRC to gain access to the PRIME-DE datasets.